Fig. 3.
Dynamic expression patterns of protein-coding genes (PCGs) during hair follicle development. a Heatmaps (left) shows the expression level (log2(FPKM+ 1)) of top 10 upregulated stage-specific PCGs across developmental stages; heatmaps (right) shows the normalized consensus scores of significantly (FDR < 0.05) enriched Gene Ontology (GO) terms for all upregulated genes at each stage by the gene set enrichment analysis (GSEA). FPKM, fragments per kilobase of exon model per million mapped fragments. b Similar to a, but for the downregulated stage-specific PCGs. c, d Motifs of transcriptional factors (TFs) are significantly enriched in promoters of upregulated and downregulated stage-specific PCGs, respectively. e K-means clusters of all stage-specific PCGs. Genes in bold are those involved in the skin and epithelium development. Corresponding biological themes and the top enriched TF motifs are shown next to each cluster