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Fig. 8. | BMC Biology

Fig. 8.

From: Comprehensive transcriptome and methylome analysis delineates the biological basis of hair follicle development and wool-related traits in Merino sheep

Fig. 8.

Integrative analysis of stage-specific molecular signatures and co-expression modules with GWAS signals of wool and growth traits. a The GWAS signal enrichment results across the stage-specific upregulated molecular features including PCGs, miRNA targets, circRNAs, circRNAs parental genes, lncRNAs, lncRNA targets, and DNA methylation. b Similar to a, but for stage-specific downregulated molecular features. c The GWAS signal enrichment results for 15 gene co-expression modules. Traits include mean fibre diameter (MFD), coefficient of variation of fibre diameter (CVFD), crimp number (CN), mean staple length (MSL), greasy fleece weight (GFW), and live weight (LW). Colour corresponds to enrichment degrees (− log10FDR) calculated using the sum-based GWAS signal enrichment analysis, where () means FDR < 0.1. d, e GHR; f PPP1R27. For left to right, the first plot is for the genetic variance explained by SNPs of SPHK1 (each dot is one SNP, and the highlighted region corresponds to gene region), the second for the expression patterns of SPHK1 across six developmental stages, the third for the expression patterns of SPHK1 across multiple tissues in sheep gene expression atlas, and the last for the results of phenome-wide association study (PheWAS) for SPHK1. e, f Similar to d, but for GHR and PPP1R27, respectively

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