Fig. 7

Signaling changes in lineage subsets during hematopoietic recovery. A Representative contour plots for pAkt and pEGFR and in DNT and B cells. Combined charts of dot plots, box plots, and fitting curves showing the frequency changes of the indicated protein positive cells in different lineage cell subsets in mice. Fitting curves in different colors indicate the changes of different differentiation routes from LMPP to T cell subsets or B cells. B Representative contour plots for pERK1/2 in CD4 and CD8 T cells. Combined charts of dot plots, box plots, and fitting curves showing the frequency changes of pERK1/2-positive cells in different lineage cell subsets in mice. C Schematic diagram showing the signaling protein changes during lymphocyte differentiation. D Representative contour plots for pS6, pERK1/2, β-catenin, and pSHP2 and in G-MDSC and M-MDSC. D, E Combined charts of dot plots, box plots, and fitting curves showing the frequency changes of the indicated protein positive cells in different lineage cell subsets in mice. Fitting curves in different colors indicate the changes of different differentiation routes from GMP to G-MDSC or M-MDSC. F Schematic diagram showing the signaling protein changes during myeloid cell differentiation. n = 4 mice in each group