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Fig. 3 | BMC Biology

Fig. 3

From: The genome of the zoonotic malaria parasite Plasmodium simium reveals adaptations to host switching

Fig. 3

Red blood cell invadome deletions. A Overview of the red blood cell invadome gene groups, reticulocyte-binding proteins (RBPs) and Duffy-binding proteins (DBPs) in Plasmodium vivax and Plasmodium simium. The P. vivax genome harbours two RBP2d genes, one of which is a pseudogene (Additional file 1: Table S5). B Schematic depiction of the hypothesised scenario in which the DBP1 deletion—along with other accumulated genetic changes in P. simium—is a prerequisite for the recently observed zoonosis. C Left: Structural rendering of DBP1, showing known structural domains and motifs. The two fragment molecules from the human DARC receptor are shown in grey. The 3-dimensional structure of the DBL-DARC complex was modelled based on the P. vivax crystallographic model (PDB 4nuv). The region deleted in sequences from human-infecting P. simium, as compared to P. vivax P01, is highlighted in red. Right: Details of DBP1 protein alignments. A full alignment is available in Additional file 3: Figure S17. D Similar to panel C but for RBP2a. The complex between the reticulocyte-binding domain and the human receptor was modelled based on the cryoEM structure of the complex between the P. vivax RBP2b and the human transferrin receptor TfR1 (PDB 6d05). A full alignment is available in Additional file 4: Figure S25

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