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Fig. 9 | BMC Biology

Fig. 9

From: Large-scale data analysis for robotic yeast one-hybrid platforms and multi-disciplinary studies using GateMultiplex

Fig. 9

Signal source formats. a Preclinical lead compound identification is the early stage in drug discovery and is composed of three screening phases. The first phase is a high-throughput screening process. Large compound types are detected in single dose, and the active hits would be selected. The second phase is a medium-throughput screening. The active hits selected from single-dose screening would be tested in serial doses to select the true-positive hits. The third phase is a low-throughput screening for validation of lead compound identification. b–d Different platforms, such as the high-throughput, the medium-throughput, and the low-throughput platforms, can generate different signal formats. Common formats include b the linear signal source and c the clustered signal source. The signal files generated from preclinical lead compound identification are usually in the clustered format. d Scattered signal source is another kind of signal format

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