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Fig. 2 | BMC Biology

Fig. 2

From: Zinc antagonizes iron-regulation of tyrosine hydroxylase activity and dopamine production in Drosophila melanogaster

Fig. 2

Catsup knockdown in dopaminergic neurons results in not only zinc but also iron sensitivities due to compartmentalized zinc toxicity. A The decreased eclosion defect of Catsup RNAi flies could be significantly rescued by hZIP7 or dZnT1 OE. Genotypes of the flies used were TH-Gal4> w1118 (control); TH-Gal4>Catsup RNAi; TH-Gal4>Catsup RNAi, dZnT1 OE; TH-Gal4>Catsup RNAi, hZIP7. All values are presented as mean ± SEM; n = 6. ***p < 0.001. B The decreased eclosion defect of Catsup RNAi flies could be significantly influenced by dietary zinc or iron. The eclosion defect became deteriorated after ZnCl2 and FAC supplementation. Genotypes of the flies used were TH-Gal4> w1118 (control) and TH-Gal4>Catsup RNAi. All values are presented as mean ± SEM; n = 6. *p < 0.05, **p < 0.01, ***p < 0.001

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