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Fig. 8 | BMC Biology

Fig. 8

From: Zinc antagonizes iron-regulation of tyrosine hydroxylase activity and dopamine production in Drosophila melanogaster

Fig. 8

A model to explain Catsup’s effect on TH activity. Zinc appears to be an important regulator of TH activity or dopamine production in vivo. When Catsup is mutated, zinc fails to be effectively redistributed between ER/Golgi and cytosol, leading to zinc elevation in the secretory pathway but reduction in the cytosol. Zinc normally antagonizes iron in regulating TH activity. When zinc release is blocked, TH has better access to iron and its activity is elevated

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