Fig. 1.

Bioinformatics pipeline and filtering process of two datasets of hearing loss genes: the classic dataset composed of non-syndromic hearing loss genes identified in humans which is composed of a total of 129 coding genes obtained by combining the information available in the “Hereditary Hearing Loss Homepage” [17], the “Genetics Home Reference – Nonsyndromic deafness related genes” website [18], the Connexin-deafness homepage – Nonsyndromic deafness related connexins” [19] and from the chapter “Deafness and Hereditary Hearing Loss Overview” from the online book “Gene Review” [20], and the recently identified hearing impairment genes by the International Mouse Phenotype Consortium [21,22,23]