Fig. 3.

Phylogenetic tree and positive selected sites of an essential tip link protein: TMC1. A Schematic diagram of the TMC1 protein domains (taken from [40]) showing the approximate localization of positively selected sites. Transmembrane domains (S1 to S6) were depicted using info from UniProtKB - Q8TDI8 (TMC1_HUMAN). B On the left: phylogenetic tree showing vertebrate species used for the analysis. The red arrow indicates the foreground branch. Mammalian species included in the foreground branch are written in red. On the right: sequence alignment of the positively selected sites identified. Positions of the human sequence given correspond to the ENST00000645208.2 transcript. Note that a change of Serine by Serine (asterisk) is identified as a positive selected site, see Fig. 2 legend for an explanation