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Fig. 5 | BMC Biology

Fig. 5

From: Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals

Fig. 5

Key genes involved in the mechanotransduction machinery display signatures of positive selection. A A network interaction map of all the 53 positively selected proteins from the STRING database (https://string-db.org). Edges represent protein associations, with either known or predicted interactions. Known interactions are represented by light-blue lines (curated databases) or purple lines (experimentally determined). Predicted interactions are represented by green (neighbors), red (fusions), and blue (co-occurrence) edges. Other interactions are represented by gold (text-mining), black (co-expression), and gray (protein-homology) lines. Interaction is observed between classical, well-known hearing genes (PCDH15, CDH23, TMC1) related to the mechanotransduction machinery and novel genes (LOXHD1), for which its role in this complex has yet to be explored but still show strong signals of positive selection. Genes involved in the tip link function are highlighted in red (B). Cellular organization of the mammalian hair cell. Genes that play key roles in hair cell function and displayed signatures of positive selection in mammals are highlighted in red. C Tip link schematic showing the location of key genes involved in function in this particular structure. Genes involved in the mechanotransduction machinery that display signatures of positive selection are highlighted in red

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