Fig. 5
From: A unified evolutionary origin for the ubiquitous protein transporters SecY and YidC
Archaeal YidC and its descendants form dimers via the same interface as proto-SecY. a Comparison of the SecY (6itc) and EMC3/6 (6wb9) dimerisation interfaces. b Archaeal and eukaryotic HHpred hits for EMC6-like proteins. A red cross and grey text indicates the first rejected result. For sequence accession numbers, see Methods. c Structures of archaeal and eukaryotic complexes containing homologs of EMC3/6 (6wb9): M. jannaschii YidC a.k.a. MJ0480/MJ0606 (predicted, see Additional file 2: Figure S4), H. sapiens TMCO1/C20orf24 (predicted, see Additional file 2: Figure S4), and H. sapiens GET1/2/3 (6so5). A sequence insertion in the N-terminal half of GET2 TM3 is shown in pink