Conventional laboratory housing increases morbidity and mortality in research rodents: results of a meta-analysis

Table 2 Meta-regression of potential moderators of housing effects on hazard ratios

	Test statistic	p
Species	F_1,27 = 0.3206	0.5759
Sex	F_1,27 = 0.1448	0.8659
Social status	F_2,27 = 0.8277	0.4479
Spontaneous or induced disease	F_1,27 = 0.0141	0.9065
Species × sex	F_1,27 = 0.0003	0.9854
Species × social status	F_1,27 = 0.0120	0.9136
Sex × social status	F_2,27 = 0.6782	0.5160
Resource category	F_1,26 = 0.0025	0.9608
After removal of ‘red flags’
Species	F_1,18 = 0.5480	0.4687
Sex	F_2,18 = 0.0773	0.9259
Social status	F_2,18 = 0.1923	0.8267
Spontaneous or induced disease	F_1,18 = 0.8882	0.3584
Species × sex	F_1,18 = 0.1946	0.6643
Species × social status	F_1,18 = 1.6277	0.2182
Sex × social status	F_2,18 = 0.5397	0.5921
Resource category	F_1,17 = 0.0595	0.8103

Results from a random-effects meta-regression investigating potential moderators of housing effects (effects of conventional housing versus housing ‘enriched’ with resources supporting species-typical behaviour) on mortality rates (hazard ratios). (See Additional file 11 for a replicate excluding study weights)

ISSN: 1741-7007