Fig. 3

Metabolic pathways present in D. papillatum. Text and arrows in light-gray do not correspond to predicted localizations. Numbers correspond to enzyme numbers in Table 1: 1. glucose oxidase; 2. hexokinase (HK)/glucokinase (GLK); 3. glucose-6-phosphatase (GPase); 4. phosphoglucose-6-isomerase (PGI); 5. pyrophosphate fructose-6-phosphate 1- phosphotransferase (PFP); 6. fructose-1,6-bisphosphatase; 7. fructose-bisphosphate aldolase; 8. glyceraldehyde-3-phosphate dehydrogenase; 9. phosphoglycerate kinase (PGK); 10. phosphoglycerate mutase; 11. enolase (ENO); 12. pyruvate kinase (PK); 13. triosephosphate isomerase; 14. glycerol-3-phosphate dehydrogenase; 15. phosphoenolpyruvate carboxykinase (PEPCK); 16. glucose-6-phosphate dehydrogenase (GPDH); 17. gluconolactonase; 18. 6-phosphogluconate dehydrogenase; 19. ribulose-5-phosphate isomerase; 20. ribulose-5-phosphate epimerase; 21. transketolase, 22. transaldolase; 23. pyruvate carboxylase (PC); 24a. pyruvate dehydrogenase component, E1 (PDH1); 24b. component of 2-oxoglutarate dehydrogenase complex; E2 (PDH2), 24c. dihydrolipoyl dehydrogenase, E3 (PDH3); 25. pyruvate:NADP⁺ oxidoreductase (PNO); 26. lactate dehydrogenase (LDH); 27. opine dehydrogenase; 28. 1-pyrroline-5-carboxylate dehydrogenase; 29. glutamate dehydrogenase; 30. citrate synthase; 31. aconitase (ACO); 32. isocitrate dehydrogenase (IDH); 33. 2-oxoglutarate dehydrogenase; 34. 2-oxoglutarate decarboxylase (OGDC); 35. succinyl-CoA synthetase; 36. succinate-semialdehyde dehydrogenase (SSDH); 37. fumarase; 38. malate dehydrogenase (MDH); 39. malic enzyme (ME); 40. carnitine-acyltransferase; 41. acyl-CoA synthetase (ACS); 42. acyl-CoA dehydrogenase; 43. enoyl-CoA hydratase (ECH); 44. 3-hydroxyacyl-CoA dehydrogenase (HADC); 45. 3-ketoacyl-CoA thiolase (KACT); 46. trifunctional enzyme; 47. acyl-CoA oxidase; 48. bifunctional enzyme; 49. ATP-citrate lyase (ACL); 50. acetyl-CoA carboxylase (ACC); 51. fatty acid synthase, type I (FAS-I); 52. thioesterase. Abbreviations: AOX, alternative oxidase; CoA, coenzyme A; DHAP, dihydroxyacetone phosphate; FRD, fumarate reductase; G3P, glycerol-3-phosphate; G3PDH, glycerol-3-phosphate dehydrogenase; GAP, glyceraldehyde-3-phosphate; I-IV, respiratory complex I-IV; LDH, lactate dehydrogenase; MQ, menaquinone; NDH2, NADH dehydrogenase; ProDH, proline dehydrogenase; UQ, ubiquinone