Fig. 5.

Effect on the behaviors of VGAT-ChR2 transgenic mice under vagus nerve optogenetic stimulation (VNOS). A The representative moving traces of the mice in an open field arena (OFA) before and during VNOS. B The total distance traveled in the OFA, entries to the center zone and time spent in the center zone (n = 8) of the OFA before and during VNOS. C The representative moving traces of the mice in an elevated plus maze (EPM) before and during VNOS. D Entries to and time spent on the open arms of the EPM (n = 8) before and during VNOS. The data are presented as mean ± standard deviation of the mean. The stars represent significant differences (**p < 0.01, paired t test)