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Fig. 3 | BMC Biology

Fig. 3

From: Co-option of the same ancestral gene family gave rise to mammalian and reptilian toxins

Fig. 3

Evolution of tetrapod toxin kallikreins. The tetrapod lineage of TKLKs evolved from an ancestral serine protease that also gave rise to vertebrate anionic trypsins. From here, the tetrapod TKLKs diverged into the KLK4-KLK15 group and the toxipotent KLK1-SVL-SVSP lineage. Proteins in KLK1-SVL-SVSP lineage are preadapted to become toxins, given their ability to regulate blood pressure when injected into the bloodstream

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