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Table 2 Kinetic parameters of Tet(X2), Tet(X4), and enzymes carrying the L282S or V329M substitutions on tigecycline

From: Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline

Protein

kcat (S−1)

KM (μM)

kcat/KM (M−1 S−1)

Tet(X2)

1.04±0.01

4.45±0.13

2.33×105

Tet(X4)

2.03±0.03

1.80±0.09

1.13×106

L282S

1.36±0.05

3.96±0.38

3.43×105

V329M

3.65±0.10

4.81±0.32

7.59×105

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BMC Biology

ISSN: 1741-7007

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