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Fig. 3. | BMC Biology

Fig. 3.

From: Meta-analysis links dietary branched-chain amino acids to metabolic health in rodents

Fig. 3.

A Orchard plots showing mean effects of increased dietary BCAAs on indicators of glucose metabolism. Thick error bars are 95% confidence intervals (CI; i.e. statistical significance) and fine error bars 95% prediction intervals (i.e. heterogeneity in reported effects; the range within which 95% of effect sizes are expected to fall), and k is the number of effect sizes (lnRR). Positive effects indicate that the outcome measure is higher on the experimental diet (with higher BCAAs) than the control diet. B Surface showing meta-regression estimate of lnRR for glucose AUC as a function of the difference in dietary BCAA and non-BCAA levels between experimental and control diets. C, D Bubble plots for lnRR of plasma insulin and HOMA as a function nutritional moderators. Red line indicates the fitted values from meta-regression, with the shaded area the CI. On surfaces, red colours indicate positive effects, blue colours negative effects and purple areas on inlaid panels indicate that the CI for that region of the surface does not span zero. All fitted values come from the AIC-favoured model (see Additional File 1: Table S5 for coefficients). E Orchard plots showing effects for each outcome stratified by whether animals were fasted or fed prior to sampling (the significance of between group contrasts are given in Additional File 1: Table S3)

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