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Fig. 1. | BMC Biology

Fig. 1.

From: Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability

Fig. 1.

PrnpZH3/ZH3 mice show reduced activity and anxiety-related behavior. a Immunoblot analysis of PrPC expression in Prnp+/+ and PrnpZH3/ZH3 mice forebrain. Actin is used as a loading control. b Representative images of Prnp+/+ and PrnpZH3/ZH3 mouse exploratory behavior in the open field test. The dotted line delineates the center and the periphery of the arena. c Mouse activity in the open field test represented as the number of lines crossed in the X + Y-axis. d Time spent (s) by the mice in the center and periphery of the open field arena. e Number of rearing and immobility episodes displayed by Prnp+/+ and PrnpZH3/ZH3 mice during the open field test. In total, 98 animals (n = 49 for each genotype) were tested individually, in rounds of two animals in parallel. Data are presented as mean ± S.E.M. **p < 0.01 and ***p < 0.001, Mann-Whitney U non-parametric test. Source data and individual data values are available in Additional file 10

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