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Fig. 2. | BMC Biology

Fig. 2.

From: Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability

Fig. 2.

Impairments in the acquisition of an instrumental learning task in PrnpZH3/ZH3 mice. a Percentage of mice reaching the selected criterion (to collect ≥ 20 food pellets for two consecutive days) in the successive training sessions. b Lever presses of Prnp+/+ and PrnpZH3/ZH3 mice during the fixed ratio (1:1) conditioning paradigm. The test was performed daily for seven consecutive days. c,d Lever presses of Prnp+/+ (c) and PrnpZH3/ZH3 (d) mice during the ON/OFF training paradigm. Lines represent best linear fits for lever presses evoked during light ON (gray) and light OFF (black) periods. Equations corresponding to regression lines are illustrated in c and d, including R2 coefficients. Data are presented as a percentage in a, and as mean ± S.E.M. in b–d. **p < 0.01 and ***p < 0.001, two-way ANOVA + Bonferroni’s multiple comparisons test. Source data and individual data values are available in Additional file 10

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