Fig. 12

A Molecular phylogenetic reconstruction of SVMP toxins with the lineage-specific amplification of particular forms shaded in pink (Colubridae), blue (Elapidae), or yellow (Viperidae). Grey shading shows the convergent evolutions of procoagulant functionally derived forms. Colours on the outside of the ring designate the convergent evolutions of the P-IIId structurally derived forms. Additional Files contain sequence alignment used for constructing phylogenetic tree (Additional file 20), tree output file (Additional file 21), and zoomable high-resolution tree image (Additional file 22). B Partial sequence alignment of representative SVMP with coloured shading of species names indicating the three convergent evolutions of inter-chain cysteines diagnostic of the P-IIId structurally derived forms. Other procoagulant functionally derived forms (species names not shaded) are included for comparison