Fig. 2

Molecular modelling of showing sites under selection by FUBAR (left) and MEME (right) colour coded to show sites that are negatively (blue and turquoise, resp), neutrally (white), or positively (red and purple resp.) selected. Protein models show front and back views coloured according to FUBAR’s estimated strength of selection (β-α, left) and MEME’s significance levels (right). See Table 1 for values and Additional file 4 for modelling templates. A 3FTx, B CRiSP, C kallikrein