Fig. 8

Sequence alignment of representative plasmin-inhibiting derived forms of kunitz toxins, with the functionally important arginine residue shaded in red. Procoagulant species with confirmed plasmin-inhibition are shaded in green. Procoagulant species which contain derived kunitz forms with the functionally important arginine but with phylogenetically distinct sequences that have not been functionally confirmed as plasmin-inhibiting are highlighted in yellow. Pseudonaja variants which lack the diagnostic arginine and have been tested for bioactivity and confirm the lack of plasmin inhibition activity are highlighted in grey