Fig. 5

Spontaneous generalized seizures (GS) in PACK and bPAC mice during LFP recordings. A Representative spontaneous electrographic GS in a PACK mouse. The hypersynchronous activity spread across both hemispheres and was followed by postictal depression. B Similar GS were recorded in bPAC mice. C, D The number of GS was counted in all LFP recording types (baseline: “ref/pre,” “light ON,” “post”) of PACK and bPAC mice, and the average number of GS in three hours is presented and compared with Friedman’s test followed by Dunn’s multiple comparisons. The occurrence of GS in baseline recordings indicates seizure generalization independent from light-induced PACK/bPAC activation. E The total count of GS in LFP recordings (9–28 h) was the highest in bPAC mice. Control mice that expressed either mCherry in CA1 or no virus experienced no seizure-like activity during recordings. Kruskal-Wallis test with Dunn’s multiple comparisons, *p < 0.05, **p < 0.05. Median presented with IQR as error bars. Individual data values are presented in Additional file 3