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Fig. 3 | BMC Biology

Fig. 3

From: Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing

Fig. 3

The upregulation of Srd5a1 by estradiol is blunted by anti-inflammatory cytokines. A Srd5a1 mRNA levels in ovaries of mice of various ages (n = 3–7). Groups sharing same letter: P > 0.05 (ANOVA, Tukey-Kramer t-test). BD In ovarian KK-1 cells: B Srd5a1 mRNA levels (n = 3) after exposure to estradiol (E2), progesterone (P4), dihydrotestosterone (DHT), or dexamethasone (Dex). For E2-treatments, #P < 0.05; ##P < 0.01 compared to controls, otherwise P > 0.05. C Srd5a1 mRNA levels after cytokine exposure in KK-1 cells (n = 3). D Also in KK-1 cells, Srd5a1 (n = 6) and Cyp19a (n = 3) mRNA levels after E2 alone (10 nM) or with cytokine (100 ng/ml); #P < 0.025, ##P < 0.01, ### P < 0.001 vs control; **P < 0.02 vs E2; where not marked P > 0.05. All graphs show mean with individual data points

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