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Fig. 2 | BMC Biology

Fig. 2

From: Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis

Fig. 2

NAA40 knockdown increases intact lipid content affecting specific DAG and TAG species. A PCA scores plot of the total lipid profiles in mock, scramble, and NAA40-KD cells after 48 h of siRNA treatment. Dark grey circles represent independent mock samples, light grey represent scramble samples and red circles represent NAA40-KD samples (n = 4/group). B PCA loadings plot showing the lipid species influence on the separation between the mock, scramble, and NAA40-KD sample groups (n = 4/group). C Sum of TAG content (n = 4/group), D sum of DAG content and (n = 4/group). E Intracellular levels of short-chain TAG (n = 4/group) and F DAG species measured by LC-MS after 48 h of siRNA treatment (n = 4/group). All data are presented as mean ± SEM and analysed by 1-way ANOVA with post hoc Dunnett’s multiple-comparisons test; *P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001. Individual values can be found in Additional file 9: Table S4

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