Skip to main content

Table 1 Inhibitory activity of 2′-hydroxyflavanone and other 13 flavonoids against AeNobo. Fifteen flavonoids, including the subclasses of flavonone, flavone, isoflavone, flavonol, isoflavan, and anthocyanidin, are illustrated in Additional file 1: Figure S3. “No inhibition” means that the IC50 value of a compound is greater than 25 μM. Among the examined chemicals, biochanin A is the only estrogenic chemical that inhibits the in vitro enzymatic activity of AeNobo. s.d. standard deviation, - not determined

From: Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti

Compound Subclass IC50 to AeNobo-WT (μM) (mean ± s.d.) IC50 to AeNobo-E113A (μM) (mean ± s.d.)
2′-Hydroxyflavanone Flavanone 4.76 ± 0.37 No inhibition
Naringenin Flavanone No inhibition -
Luteolin Flavone 3.99 ± 0.46 35.8 ± 5.73
Biochanin A Isoflavone 1.84 ± 0.06 No inhibition
Daidzein Isoflavone 3.87 ± 0.52 No inhibition
(+) Catechin hydrate Flavonol No inhibition -
Fisetin Flavonol 1.69 ± 0.04 No inhibition
Kaempferol Flavonol 4.91 ± 1.69 No inhibition
Myricetin Flavonol 2.91 ± 0.27 No inhibition
Quercetin Flavonol 0.963 ± 0.094 No inhibition
Tamarixetin Flavonol No inhibition -
S-equol Isoflavan No inhibition -
Cyanidin chloride Anthocyanidin 2.15 ± 0.24 No inhibition
Petunidin Anthocyanidin 14.9 ± 2.01 No inhibition