Table 2 Inhibitory activity of daidzein derivatives against AeNobo. Daidzein derivatives used in this study are illustrated in Fig. 3A. Besides IC50 values, this table shows the presence of the hydroxyl residues (-OH) in the carbon positions of isoflavone nuclei. For example, luteolin possesses the hydroxyl residues at C3′, C4′, C5, and C7 position of the isoflavone nuclei. “No inhibition” means that an IC50 value of a compound is larger than 25 μM. s.d. standard deviation
Compound | C4′ | C5 | C6 | C7 | IC50 (μM) (mean ± s.d.) |
|---|---|---|---|---|---|
Daidzein | -OH | -OH | 3.87 ± 0.52 | ||
Genistein | -OH | -OH | -OH | 1.86 ± 0.41 | |
7-Hydroxyisoflavone | -OH | 5.61 ± 0.30 | |||
3-(4-Hydroxyphenyl)-4H-chromen-4-one | -OH | No inhibition | |||
Desmethylglycitein | -OH | -OH | -OH | 0.293 ± 0.012 |