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Fig. 7 | BMC Biology

Fig. 7

From: Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy

Fig. 7

Increased expression of hyaluronidase-1 drives endothelial abnormalities in PCV. Phenotypes indicative of vascular instability were observed in PCV patient-derived endothelial cells under heterogeneous flow conditions. Increased HYAL1 expression in PCV cells led to impaired glycocalyx through the degradation of HA components, giving rise to an altered response to flow, increased cell migration and barrier permeability

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BMC Biology

ISSN: 1741-7007

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