Fig. 8

Hypothetical model for the functional differentiation of Asn-type and Asp-type CFEM-containing VdSCPs from Verticillium dahliae. Under the iron-insufficient environment of xylem, on the one hand, V. dahliae employs the Asp-type CFEM members (VdSCP33, VdSCP41, VdSCP43, VdSCP72, VdSCP99, VdSCP116, VdSCP120) to sequester iron that further aggravates the iron deficiency in the xylem and reduces host resistance; on the other hand, V. dahliae employs Asn-type CFEM members (VdSCP76, VdSCP77) to suppress immunity directly and to promote successful colonization. FRO: ferric-chelate reductase. IRT: iron-regulated transporter. N and D represent asparagine (Asn) type and aspartic acid (Asp) type CFEM-containing VdSCPs from V. dahliae, respectively