Table 1 Transcription factors whose motif are enriched in genes up-regulated in WRF and their involvement in cardiovascular diseases

 ELK1, ELK4

Involved in the cardiac gene regulatory network

[38]

 ETS1

Mediates angiotensin II-related cardiac fibrosis and cardiac hypertrophy

[32, 33]

 ETV1

Induces atrial remodeling and arrhythmia

[34]

Determine fast conduction physiology in the heart

[39]

 ERG

Regulates endothelial-specific gene expression program

[40]

 NRF1

Loss in cardiomyocytes leads to apoptosis and reduced left ventricular function

[41]

 KLF3

Involved in cardiovascular development and function

[35]

 KLF6

Decreased expression in cardiomyocytes reduces cardiac fibrosis

[36]

 IRF8

Suppresses pathological cardiac remodeling

[37]