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Fig. 4 | BMC Biology

Fig. 4

From: Diurnal and circadian rhythmicity of the human blood transcriptome overlaps with organ- and tissue-specific expression of a non-human primate

Fig. 4

Examples of tissue/organ-specific rhythmic genes in baboon and orthologous transcripts also rhythmic in human whole blood. Tissue/organ-specific rhythmic gene examples for a MMB, mammillary bodies, b PVN, paraventricular nuclei, c LGP, lateral globus pallidus, d HEA, heart, e KIC, kidney cortex, f BLA, bladder, g COR, cornea and h AXL, axillary lymphonodes. For each tissue/organ-specific rhythmic gene (gene symbol at top of each panel), the z-scored expression profiles are plotted against time since the start of light for the baboon in purple (Ensembl ID for baboon genes provided in symbol legend) and for the orthologous human transcript in solid red line (mean ± SD for interpolated data points and just mean for double-plotted data points, actual data points for each participant are shown in grey) for the baseline diurnal plots (n = 19 participants), and as a dashed green line for the circadian plots (n = 19 participants) (human transcript Agilent probe IDs provided next to symbol legends). In each panel, the strength of circular cross-correlation between the alignment of the baboon expression profile and the human diurnal expression profile is listed (xcor), together with the lag in hours between the expression profiles. The relative light/dark cycles for baboon (purple) and human diurnal (red) conditions are indicated as horizontal bars below the plots (white = light, black = dark). For each gene, the function of its coded protein (where know) is listed below the gene symbol

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