Fig. 7

Effect of external phase reference marker on phase relationship in baboon and human blood transcriptome. We calculated the circular cross-correlation and associated lag between the baboon expression profile and the human diurnal expression profile for all overlapping rhythmic genes. The circular cross-correlation and lags were calculated in every overlapping rhythmic gene (n = 4214) based on alignment with start of light, midpoint of light and end of light. The resulting three lags per gene, per baboon tissue, were ranked such that the alignment with the smallest lag is given the top rank (1). a Heatmap and b histogram of ranked lags of all overlapping rhythmic genes, where ranking was performed within gene across the three different alignments