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Fig. 2 | BMC Biology

Fig. 2

From: Dopamine D1- and D2-like receptors oppositely regulate lifespan via a dietary restriction mechanism in Caenorhabditis elegans

Fig. 2

Pharmacological activation or inhibition of D2R exerts opposite effects on the lifespan of C. elegans. A Survival curves of wild-type (N2) worms cultured at 20 °C on NGM plates containing different concentrations of aripiprazole (Ari). DMSO treatment was used as a control. B Survival curves of N2 worms treated with the indicated concentrations of quetiapine (Que) or DMSO at 20 °C. (aripiprazole and quetiapine treatment were compared with the DMSO treatment: **indicated P < 0.01. ***, P < 0.001. ****, P < 0.0001, log-rank test). C Dose-response curve of aripiprazole (Ari) and quetiapine (Que) treatment. (see Additional file 2 for supporting data). Experiments were performed in three independent biological replicates

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BMC Biology

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