Fig. 4

Aripiprazole mediates lifespan extension through D2R signaling. Survival curves of mutant goa-1 (A), acy-1 (B), kin-1 (C), dgk-1 (D), pkc-1 (E), pkc-2 (F), pkc-3 (G), tpa-1 (H), dkf-1 (I), dkf-2 (J), egl-30 (K), and egl-8 (L) treated with 100 μM of aripiprazole (Ari) or DMSO at 20 °C (comparison between DMSO and Ari treatment: ns = not significant with P > 0.05; **indicated P < 0.01. ****, P < 0.0001 with log-rank test) (see Additional file 2 for supporting data). Experiments were performed in three independent biological replicates