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Fig. 5 | BMC Biology

Fig. 5

From: Dopamine D1- and D2-like receptors oppositely regulate lifespan via a dietary restriction mechanism in Caenorhabditis elegans

Fig. 5

Aripiprazole extends worm lifespan through a dietary restriction mechanism. A Survival curves of the eat-2 mutant treated with 100 μM of aripiprazole (Ari) or DMSO at 20 °C (comparison between DMSO and Ari treatment: ns = not significant, P > 0 .05. **, P < 0.01. ****, P < 0.0001, log-rank test). B Fast body movement spans of wild-type (N2) worms cultured at 20 °C on NGM plates containing indicated concentrations of aripiprazole (Ari) or DMSO. C, D Changes in brood size (C) and reproductive span (D) of N2 animals treated with or without 100 μM of aripiprazole (Ari) (comparison between DMSO and aripiprazole (Ari) treatment: ****, P < 0.0001, t-test). E Representative images of ORO staining of worms treated with or without aripiprazole (Ari) for 7 days. Scale bar = 200 μm. F Relative ORO intensity of worms treated with or without aripiprazole for 7 days (comparison between DMSO and aripiprazole (Ari) treatment: ****, P < 0.0001, t-test). G Pharyngeal pumping rate of N2 worms treated with 100 μM of aripiprazole (Ari) or DMSO for 5 days (comparison between DMSO and Ari treatment: **** indicated P < 0.0001, t-test). (see Additional file 2 for supporting data). The brood size assay was performed in two independent biological replicates. Other experiments were performed in three independent biological replicates

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