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Fig. 7 | BMC Biology

Fig. 7

From: Dopamine D1- and D2-like receptors oppositely regulate lifespan via a dietary restriction mechanism in Caenorhabditis elegans

Fig. 7

A schematic diagram of the possible mechanism of dopamine receptor signaling-mediated lifespan regulation. In C. elegans, DOP-2 signaling extends lifespan while DOP-4 signaling shortens lifespan. Pharmacological activation of DOP-2 using aripiprazole extends lifespan, whereas inhibition of DOP-2 using quetiapine shortens lifespan. Aripiprazole extends lifespan through a DR mechanism mediated by the AAK-2-DAF-16 pathway. The DAG-PKC/PKD pathway served as a link between dopamine receptors and the AAK-2-DAF-16 pathway to transmit longevity signals. The role of DOP-4 in lifespan regulation requires further investigation

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BMC Biology

ISSN: 1741-7007

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