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Fig. 5 | BMC Biology

Fig. 5

From: An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients

Fig. 5

\(\dot{\varepsilon}\)-S [Ca2+]c flux is dependent on mechanically gated calcium influx. A Ca2+ sampling along T14 in θ = 80° stenosis geometry following treatment of reconstituted blood (10 min) with DMSO − vehicle control (N = 8 experiments); PGE1 (100 nM) + Thephylline (10 mM) [N = 3 experiments]; APB2 (50 mM) to inhibit IP3 receptor (N = 4 experiments); U73122 (2 mM) to inhibit phospholipase C (N = 4 experiments). B Ca2+ sampling along T14 in θ = 80° stenosis geometry following treatment of reconstituted blood (10 min) with, DMSO − vehicle control (N = 13 experiments); EGTA (1 mM) to chelate extracellular Ca2+ (N = 4 experiments); Gadolinium (30 μM) [N = 4 experiments]; Ruthenium Red (30 μM) [N = 3 experiments]; SAR7334 (1 μM) to inhibit TRPC6 channels (N = 5 experiments)

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