Fig. 3

Response of cones to rod degeneration at P21. Two-dimensional UMAP plot of cluster C04 containing cone photoreceptors, colored according to A genotype or B normalized expression levels of Egr1. C Dot plot of all differentially expressed genes with absolute average log fold change > 0.5 and adjusted p-value < 0.05 among rd10 and wild-type cones. Heatmap depicts scaled expression values for individual cells. Genes were sorted on the y-axis based on average log fold change values. D Spearman’s correlation scores for average normalized gene expression between rod clusters C01-03 and cone cluster C04. Cone cluster C04 was separated into two groups according to genotype. 5000 most variable features in the dataset were used for calculating scores. wt, wild type