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Fig. 3 | BMC Biology

Fig. 3

From: Thyroid and endostyle development in cyclostomes provides new insights into the evolutionary history of vertebrates

Fig. 3

Expression profiles of the genes involved in thyroid development in modern cyclostomes. AI and JU’ hagfish and lamprey embryos, respectively. V, W, X schematic of the Nkx2-1/2-4 expressing domain (colored red) in hagfish, lamprey, and catshark embryos when the expression of Nkx2-1/2-4 first detected in this study (stages 45, 23, and 24, respectively). A’, D’, G’, K’, L’, S’, T’ Filled and open arrowheads indicate the presence and absence of signals, respectively. K’, L’, M’, O’, P’, Q’, S’, T’, and U’ Transverse sections of hybridized embryos in the plane of the dashed lines. M’, Q’, U’ Diagram of gene expression in the endostyle is shown in the boxes. as, aortic sac; opm, vestigial oropharyngeal membrane; MHB, midbrain-hindbrain boundary; ma, mandibular arch; liv, liver; hyp, hypothalamus; ve, velum; pn, pronephros. See Figs. 1 and 2 for other abbreviations. Bars, 200 μm

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