Fig. 4.

Inhibiting DCN CaMKII α-hM4Di-positive cell activity during noise exposure does not interfere with hearing at the tested frequencies. A Timeline of experiments highlighting ABR recordings before and after noise exposure. B, C Representative ABR traces (B) and group responses for hM4Di (C left) and eYFP (C right) injected mice that received i.p. CNO injection 30 min before noise exposure. D, E ABR Wave 1 (W.1) amplitudes at 80dBSPL (left) and growth functions (right) for the hM4Di (D) and eYFP (E) injected animals that received CNO before noise exposure. Left, amplitude of wave 1 for each frequency tested 3d before (blue) and 3d after (orange) noise exposure. Right, wave 1 amplitude at each tested intensity, normalized by amplitude at 80dBSPL, at each tested frequency (cold blue-green colors: 3d before; warm red-yellow colors: 3d after noise exposure). n = 6 and 6 for NE+CNO hM4Di+ and NE+CNO eYFP