Table 1 Firing rate, tuning width, and best frequency features for each experimental group (NE hM4Di+ — animals exposed to noise expressing CaMKII α-hM4Di, n=11 mice; or NE+CNO hM4Di — animals exposed to noise under effect of CNO, expressing CaMKII α-hM4Di, n=6 mice) and each respective control (NE eYFP — animals exposed to noise expressing CaMKII α-eYFP, n=7 mice; or NE+CNO eYFP — animals exposed to noise under effect of CNO, expressing eYFP, n=6 mice) represented as mean ± standard error of the mean (SEM). Unit responses are further subdivided based on the applied treatment (NaCl or CNO) and on the CNO response in relation to NaCl (All — all units; Decreased and Increased — units that show a decrease or an increase in that feature under effect of CNO, respectively). All p values were Bonferroni-corrected for multiple comparisons

Firing rate (Hz; mean ± SEM)

NE hM4Di+

15.85 ±1.95

8.96 ±1.53

17.45 ±2.32

5.57 ±1.22

9.92 ±2.92

21.52 ±4.82

NE eYFP

14.36 ±1.67

13.21 ±1.62

20.35 ±3.04

9.23 ±2.2

9.61 ±1.55

16.38 ±2.25

NE+CNO hM4Di+

9.37 ±0.67

8.45 ±0.6

9.9 ±0.92

7.06 ±0.69

8.43 ±0.88

10.88 ±1.08

NE+CNO eYFP

4.81 ±0.68

4.24 ±0.59

5.77 ±1.09

3.23 ±0.59

4.04 ±0.81

5.9 ±1.14

Tuning width (a.u.; mean ± SEM)

NE hM4Di+

0.78 ±0.01

0.74 ±0.01

0.82 ±0.01

0.72 ±0.02

0.71 ±0.02

0.78 ±0.02

NE eYFP

0.67 ±0.01

0.69 ±0.01

0.71 ±0.01

0.62 ±0.03

0.65 ±0.02

0.73 ±0.01

NE+CNO hM4Di+

0.61 ±0.01

0.63 ±0.01

0.59 ±0.02

0.53 ±0.02

0.62 ±0.01

0.69 ±0.01

NE+CNO eYFP

0.38 ±0.02

0.4 ±0.02

0.42 ±0.03

0.36 ±0.03

0.35 ±0.03

0.43 ±0.03

Best freq. (kHz; mean ± SEM)

NE hM4Di+

12.16 ±0.22

12.83 ±0.21

14.4 ±0.23

10.53 ±0.25

10.54 ±0.24

14.07 ±0.21

NE eYFP

12.37 ±0.18

12.52 ±0.23

13.19 ±0.25

9.96 ±0.21

10.94 ±0.17

14.57 ±0.13

NE+CNO hM4Di+

12.15 ±0.15

11.7 ±0.15

12.86 ±0.2

10.0 ±0.1

10.52 ±0.2

13.22 ±0.24

NE+CNO eYFP

10.87 ±0.21

10.91 ±0.2

12.74 ±0.42

10.09 ±0.21

10.11 ±0.2

12.39 ±0.38