Fig. 3
Modeling analysis of the dose-dependent output of the central p53-Mdm2 negative feedback showed a distinct mode of p53 transitional dynamics. A Simulation results of the dose response of p53 dynamics upon increasing Nutlin-3a concentrations. B Distributions of the values of the kinetic parameters involved in the p53-Mdm2 negative feedback as formulated in Eqs. (1) and (2), which can result in periodic pulsing of p53 at 1 μM Nutlin-3a. C Dependence of the p53 pulsing period (left panel) and pulsing amplitude (right panel) (at 1 μM Nutlin-3a) on τm, the time delay in p53-induced Mdm2 upregulation