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Fig. 3 | BMC Biology

Fig. 3

From: Experimental demonstration of tethered gene drive systems for confined population modification or suppression

Fig. 3

TARE drive inheritance. Individuals heterozygous for the TARE drive were crossed with w1118 individuals, and EGFP expression in progeny indicated the presence of the drive. The size of the dots is proportional to the number of adult progeny from a single drive individual. The rate estimates and standard error of the mean (SEM) are indicated. The increased inheritance in the progeny of females is due to elimination of progeny carrying no drive alleles due to maternal Cas9/gRNA deposition causing disruption in wild-type alleles inherited from the male parent. Inheritance is Mendelian in males due to lack of maternal deposition, even though h alleles are still disrupted in the male germline

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