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Fig. 4 | BMC Biology

Fig. 4

From: The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract

Fig. 4

Prenatal exposure to E3 reduces the anxiety level of adult offspring. Eight-week-old pregnant female CD-1 mice were treated with vehicle DMSO (CT) or E3 (E3). At 6 months after birth, the offspring were subjected to a 20 min-open field test and light/dark transition test. A A representative result of the open field test. The red rectangles indicate the central area of Path tracking. The distance travelled in millimeters that a mouse travelled in the central zone. The total time in seconds that a mouse spent in the central zone. The number of entries in the central zone. The total distance in millimeters that a mouse travelled in the whole field. B A representative result of the light/dark transition test. Path tracking in the light/dark compartment; Duration (seconds): the time spent in the light/dark compartment. Percent of total time spent in the light zone and in the dark zone. Error bars: mean + SEM. *, p < 0.05; **, p < 0.01 by Student t test. The number of mice per experimental group: 11 CT male, 14 CT female, 12 E3 male, 10 E3 female

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