Fig. 5
Prenatal exposure to E3 alters mRNA expression of anxiety-related genes in the adult offspring cortex. Eight-week-old pregnant female CD-1 mice were treated with vehicle DMSO (CT) or E3 (E3). At 6 months after birth, the gene expression in the offspring cortices were assessed by microarray and anxiety-related genes were validated by quantitative RT-qPCR. A Quantification of anxiety-related genes in the female offspring hippocampus, B, C in the male offspring cortex, and D, E female offspring cortex. Error bars: mean + SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001 by Student t test. N = 10/group