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Fig. 2 | BMC Biology

Fig. 2

From: ASC proneural factors are necessary for chromatin remodeling during neuroectodermal to neuroblast fate transition to ensure the timely initiation of the neural stem cell program

Fig. 2

Proneurals target many genes and pathways that convey neuroblast homeostasis. A Gene Ontology analysis of proneural targeted genes, biological processes (BP), molecular function (MF), and cellular compartment (CC). B Overlap of Flybase neuroblast genes with proneural targets shown in the 5 consecutive waves of NB specification S1-S5. Numbers under the neuroblast IDs represent the number of proneural targets over the total Flybase NB-specific genes. Boxed inset lists the sum of the proneural bound neuroblast markers. C Proneurals regulate a holistic neuroblast program. A schematic summary of selected terms. D BDGP in situ enrichments of proneural target genes. E A venn diagram of proneural bound genes from the enriched BDGP terms in D. “VNE primordium” is the gene set from the second column of panel D; “NBs” comes from the 4th column of panel D; “Neuron” comes from the 6th column of panel D and “Epidermis” from the 12th column. Flymine outputs of candidate target genes (homer) near proneural peak consensus binding events; Gene Ontology, Protein Domain Enrichment, and BDGP in situ database Enrichment is provided in Additional file 2: Table S3

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BMC Biology

ISSN: 1741-7007

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