Fig. 3

Systemic HU210 administration altered synaptic transmission in D1 MSNs but not in D2 MSNs. A, B Representative recording traces of mEPSCs of D1 MSNs and D2 MSNs in the vehicle and HU210-treated group, respectively. C Summary of mEPSC peak amplitude (pA) (left) and frequency (right) from D1 MSNs of vehicle and HU210 group. D Summary of mEPSC peak amplitude (pA) (left) and frequency (right) in D2 MSNs recorded from animals treated with vehicle or HU210. Vehicle, mice were administered with vehicle; HU210, mice were administered with HU210 at a dose of 15 μg/kg. mEPSC frequency: Vehicle D1, n = 16, N = 5, HU210 D1, n = 16, N = 5. Vehicle D2, n = 14, N = 4; HU210 D2, n = 12, N = 4; mEPSC amplitude: Vehicle D1, n = 16, N = 5, HU210 D1, n = 16, N = 5. Vehicle D2, n = 13, N = 4; HU210 D2, n = 13, N = 4. n: cell number; N: animal number. Data shown as mean ± SEM. ANOVA: *p < 0.05, **p < 0.01