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Fig. 5 | BMC Biology

Fig. 5

From: Acute cannabinoids impair association learning via selectively enhancing synaptic transmission in striatonigral neurons

Fig. 5

Inhibiting the activity of D1 MSNs after HU210 administration prevents the impairment of NRL. A The injection site of AAV-DIO-hM4Di-mCherry virus. B The experimental procedure. C Electrophysiological recordings of representative D1 MSNs infected with hM4Di virus recorded before and after 10 μmol/L CNO perfusion. D Escape latencies curves of two groups (Control-mCherry vs. DREADD-hM4Di). E–G After CNO and HU210 administration, the DREADD-hM4Di group exhibited significantly decreased tELS (E), failures (F), and TMCS (G) during NRL compared with the Control-mCherry group. Control-mCherry, mice were injected with rAAV-hSyn-DIO-mCherry virus; DREADD-hM4Di, mice were administrated with rAAV-hSyn-DIO-hM4Di-mCherry virus. Control-mCherry: n = 6; DREADD-hM4Di: n = 6. Data shown as mean ± SEM. ANOVA (D), unpaired t-test (E), and Mann-Whitney test (F, G): **p < 0.01, ***p < 0.001

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BMC Biology

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