Table 2 Downregulated tip-enriched genes with known functions in kidney development. 19 out of 39 genes with previously characterized tip-specific expression pattern play well-known functions in ureteric bud morphogenesis and are cited in references column

Nrtn

Davies et al. [57]

Etv5

Lu et al. [54]; Kuure et al. [55]

Wnt11

Majumdar et al. [58], O’Brien et al. [59]

Etv4

Lu et al. [54]; Kuure et al. [55]

Cxcl14

Schmidt-Ott et al. [28]

Ccnd1

Ihermann-Hella et al. [39]

Adamts18

Rutledge et al. [60]

Ror2

Nishita et al. [61]

Ret

Schuchardt et al. [62]; reviewed in Costantini [63]

Spry4

Zhang et al. [64]

Hs3st3b1

Rutledge and McMahon [65]

Sox8

Reginensi et al. [50]

Mycn

Stanton et al. [66]; reviewed in Hohenstein et al. [67]; Pan et al. [68]

Gfra1

Cacalano et al. [69]; Enomoto et al. [70]; reviewed in Costantini [63]

Ctnnd2

Rutledge et al. [30]

Frem2

Jadeja, et al. [71]; Kiyozumi, et al. [72]

Rprm

Magella et al. [73]

Stmn1

Li et al. [30]