Fig. 2.

The effect of SBS2 and SBS13 presence on genomic instability. Measures of genomic instability by presence of SBS2- and SBS13-related signatures. PGA, Percentage of the Genome Altered. INDELs, Insertions and Deletions. ID8, insertion and deletion signature 8. ID6, insertion and deletion signature 6. (Wilcoxon Rank Sum test; * = p <0.05, ** = p <0.01, *** = p <0.001, n = 2451 for INDELs, ID8, ID6, PGA and Copy Number Segments. n = 2427 for SVs.). Individual p values are provided in Additional file 1: Supplementary Table 4